Recent increases in pneumonia cases have involved various respiratory pathogens. Besides influenza virus, coronavirus, and mycoplasma infections, the respiratory syncytial virus (RSV) also significantly contributes to severe respiratory infections. In the search for novel therapeutics against RSV, an interdisciplinary research team led by Professor Billy NG from the CU Medicine, designed and synthesized novel antiviral… Read More »Discovery of Novel Antiviral Drug Candidates
Previous News & Events
Dragon culture scholarship
Faculty Academic Prizes 2021-22 & Scholarships 2022-23 (Dragon Culture PhD Scholarships for Medical Studies) Behzad Nasiri Ahmadabadi Well Established Lung Cancer Organoid Model (WELCOM) for personalized medicine and drug screening project, The fast turnaround time, the combination drug testing platform and the actionable readout would inform disease prognosis and treatment decisions. The application was for… Read More »Dragon culture scholarship
Comparison of the mucosal and systemic antibody responses in Covid-19 recovered patients with one dose of mRNA vaccine and unexposed subjects with three doses of mRNA vaccines
A dose of mRNA vaccine enhanced the mucosal antibody of Covid19 recovered patients with expanded immunoglobulin isotypes and better inhibition against omicron. See our new paper published today in the Frontiers in Immunology.
Exome Sequencing Reveals SLC4A11 Variant Underlying Congenital Hereditary Endothelial Dystrophy (CHED2) Misdiagnosed as Congenital Glaucoma
In this study, we identified a family with congenital hereditary endothelial dystrophy (CHED2), which may be misdiagnosed as primary congenital glaucoma (PCG) due to similar clinical phenotypes during early infancy. A homozygous missense variant c.2024A>C, p.(Glu675Ala) in SLC4A11 was identified in the patients in this family. Our findings suggest that genome-wide neonatal screening is worthwhile… Read More »Exome Sequencing Reveals SLC4A11 Variant Underlying Congenital Hereditary Endothelial Dystrophy (CHED2) Misdiagnosed as Congenital Glaucoma
Joint Publication between HK-HOPE and HKCH PICU
The Sequential Use of Extracorporeal Cytokine Removal Devices in an Adolescent With COVID-19 Receiving Continuous Renal Replacement Therapy: It is excited to have the first joint publication with Dr Alvin Hui in the Paediatric Intensive Care Unit in the Hong Kong Children’s Hospital. Thanks for the full support of Prof CK Wong in CUHK-ChemPath.
Deciphering the complexity of simple chromosomal insertions by genome sequencing
Publication in Human Genetics Published 29 July 2020 Chromosomal insertions are thought to be rare structural rearrangements. In this study, we sequenced 16 cases with apparent simple insertions previously identified by karyotyping and/or chromosomal microarray analysis. Additional cryptic rearrangements were identified in 68.8% of the cases (11/16). Overall, our study provide molecular characterization of karyotypically… Read More »Deciphering the complexity of simple chromosomal insertions by genome sequencing
EMBO report Poster Prize Winner
Congratulations to Shaojun Liu, PhD Yr 2 student of Prof Renee WY Chan’s team for winning the poster prize at the 16th World Immune Regulation Meeting. Shaojun has been working in the nasal mucosal and #plasma #antibody responses in #SARSCoV2 mRNA #vaccine (BNT 162b2) recipients with or without prior SARSCoV2 #infection since Jan 2020.
Suppression of influenza virus infection by rhinovirus interference – at the population, individual and cellular levels
Our study by Tao et al. on rhinovirus interference in inhibiting influenza virus in population, individual and cellular levels is published. A collaboration of CUHKPaediatrics with Marc Chong SPHPC, Samuel Chow ENT, Calvin Ng Surgery, Paul Chan MicBio. Click here to see the full paper.
Post-translational modifications on the retinoblastoma protein
Our study in Journal of Biomedical Science summarized the post-translational modifications of the retinoblastoma susceptibility protein (pRb). Inactivation mutation on pRb was first identified as a cause of retinoblastoma in children. In addition, retinoblastoma survivors higher chance to develop other cancers. A better understanding of post-translational modifications on pRb is important for developing novel and specific therapeutic… Read More »Post-translational modifications on the retinoblastoma protein
Dr Wai Kit Chu has been appointed as a committee member in the Association for Research in Vision and Ophthalmology (ARVO)
Dr Wai Kit Chu has been appointed to serve in the Global Members Committee (GMC) of the Association for Research in Vision and Ophthalmology (ARVO) for 3 years. His work will assess the needs of non-U.S. based members and recommends ways to increase participation in ARVO. ARVO was founded in 1928 in USA. It is… Read More »Dr Wai Kit Chu has been appointed as a committee member in the Association for Research in Vision and Ophthalmology (ARVO)
