Dr Hui will research on ‘The role of biomarkers and clinical parameters in acute kidney injury among critically ill children’ in attachment with the mentors in the Department of Paediatrics, CUHK. This study will provide solid data for the development of new AKI diagnostic tools using urinary biomarkers in a local setting. Specifically, the application… Read More »Welcome our DH Chen Fellowship Awardee – Dr Alvin Hui

Our study in Lancet Global Health highlights the global disparity between high income and low-income countries in terms of retinoblastoma survival and globe salvage rate, and identifies socioeconomic risk factors associated with both. This information will be useful to raise awareness among policy makers and nongovernmental organizations as well as to guide resource allocation for retinoblastoma… Read More »Associations of Global Retinoblastoma Survival and Globe Preservation with Socioeconomic and Healthcare Factors

Early and intense nasal S1-specific IgA levels link to a rapid decrease in viral load. Our results provide insights into the role of mucosal immunity in SARS-CoV-2 exposure and protection. There may be a role of NELF IgA in the screening and diagnosis of SARS-CoV-2 infection. Click here for the Full paper.

Dr Mars Tao completed this collaborative work with Dr Cong Ma of the Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University. Novel secondary amine derivatives of oseltamivir CUHK326 (6f) and CUHK392 (10i), which bear heteroaryl groups of M2-S31 proton channel inhibitors, significantly reduced the plaque size of seasonal influenza A and… Read More »Inhibition of Influenza Virus Replication by Oseltamivir Derivatives

Feel honoured to be selected as one of the top viewed spontaneous articles from 2021 published in Frontiers-Vaccines and Molecular Therapeutics. #Comirnaty induces both nasal mucosal and systemic immune responses against #SARSCoV2. Click here for the Full paper.

Bone marrow transplantation has been an essential procedure for the treatment of various malignant and non-malignant diseases, with the clinical outcome significantly dependent on the quality and quantity of hematopoietic stem and progenitor cells (HSPCs) in the graft. In this study, Professor Leung’s team presented new evidence on the dynamic expression of R4 subfamily RGS… Read More »Prof. KT Leung published an article in Blood Advances

The Research Grant Council (RGC) has recently announced the results of the 2020-21 funding exercise of the General Research Fund (GRF). The HK-HOPE Ophthalmology team has demonstrated their high quality research and has obtained two research grants. Prof Chi Pui Pang, “Mapping the Thyroid Associated Orbitopathy (TAO) Genes by Whole Genome Sequencing (WGS)” (HK$1,157,652). Dr… Read More »Congratulations To Prof Chi Pui Pang And Dr Wai Kit Chu Awarded General Research Fund (GRF)

Direct Grant for Research 2019/2021 (4/6/2020) Chromosome insertions are known to cause human diseases but by conventional cytogenetics, the incidence is rare and estimated at 1 in 8,000 live births. However by genome sequencing, we discovered a novel type of insertion, which involves tandem repeat in the flanking regions of the insertion loci. This is… Read More »Comprehensive investigation of the underlined mechanism for a rare and novel replication insertion

Direct Grant for Research 2020/2021 (3/6/2021) The genetic landscape of male infertility is highly complex, with over 2000 genes involved in spermatogenesis. This study aims to investigate breakpoint junctions of apparently balanced chromosomal structural rearrangements of azoospermic males by genome sequencing. We hypothesize that molecular delineation of breakpoint junctions will enable discovery of gene disruption… Read More »Investigation of underlying mechanisms of azoospermia in balanced chromosomal structural rearrangement carriers

Publication in Genetics in Medicine Published 26 March 2021 Absence of heterozygosity (AOH) is a genetic characteristic known to cause human genetic disorders through autosomal recessive or imprinting mechanisms. Low-pass genome sequencing enabled genome-wide detection of AOH at 5Mb resolution to detect clinically relevant aberrations. Our AOH detection algorithm was performed on genome sequencing data… Read More »Low-pass genome sequencing-based detection of absence of heterozygosity: validation in clinical cytogenetics