Dr Mars Tao completed this collaborative work with Dr Cong Ma of the Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University. Novel secondary amine derivatives of oseltamivir CUHK326 (6f) and CUHK392 (10i), which bear heteroaryl groups of M2-S31 proton channel inhibitors, significantly reduced the plaque size of seasonal influenza A and B, and performed similarly to oseltamivir carboxylate at their corresponding half-maximal inhibitory concentration (IC50). These compounds showed an inhibitory effect on the oseltamivir-resistant strain under 10 nM with a selective index (SI) of >200. Full paper can be viewed here.
Inhibition of Influenza Virus Replication by Oseltamivir Derivatives
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