Doctor Feng Bo

Doctor Feng Bo

CUHK Employment

Associate Professor

School of Biomedical Sciences

Phone Number

+852 3943 1455

Email

fengbo@cuhk.edu.hk

Research Theme

Cancer

Biography

Prof. FENG Bo (馮波) is an Associate Professor in the School Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong (CUHK). She is an active staff member in the Developmental and Regenerative Biology Thematic Research Program, Institute for Tissue Engineering and Regenerative Medicine, MOE Key Laboratory for Regenerative Medicine and CUHK-GIBH Joint Laboratory on Stem Cell and Regenerative Medicine. Prof. Feng graduated from Nankai University with B.Sc. (1993) and M.Sc (1996), and received her Ph.D. (2006) from National University of Singapore. After graduation, Prof. Feng joined Prof. Ng Huck Hui’s lab in Genome Institute of Singapore as a postdoc. She worked on stem cells and reprogramming and published her works in Nature Cell Biology, Cell Stem Cell and Nature. In Nov 2010, Prof. Feng joined CUHK and her current research interest lies within the molecular mechanism that controls pluripotency and differentiation of ESCs/iPSCs, as well as development of new tools for gene and cell-based therapy.

Research Interests

  • AAV and CRISPR technology.
  • T cells engineering for cancer treatment.
  • Gene and Cell Therapy for inherited disorders and infectious diseases.
  • Molecular mechanisms that control stem cell self-renewal and differentiation.
  • Generation of iPS cells and study of reprogramming process.

 

Publication

  • Wang, J., Zhang, C., & Feng, B.# (2020). The rapidly advancing Class 2 CRISPR-Cas technologies: a customizable toolbox for molecular manipulations. J Cell Mol Med., 24(6),3256–3270. doi: 10.1111.
  • Zhang, C, He. X., Kwok, Y.K., Wang, F., Xue, Y., Zhao, H., Suen, K.W., Wang, C.C., Ren, J., Chen, G.G., Lai, B.S., Li, J., Xia, Y., Chan, A.M., Chan, W.Y., & Feng, B.# (2018). Homology-independent multiallelic disruption via CRISPR/Cas9-based knock-in yields distinct functional outcomes in human cells. BMC Biology, 16(151).
  • He, X., Li, Y.X., & Feng, B.# (2018). New Turns for High Efficiency Knock-In of Large DNA in Human Pluripotent Stem Cells. Stem Cells International, doi:9465028.
  • Ma, X., Wong, A.S., Tam, H.Y., Tsui, S.Y., Chung, D.L., & Feng, B.# (2018). In vivo genome editing thrives with diversified CRISPR technologies Zoological Research, 39(2), 58-71, doi: 10.24272/j.issn.2095-8137.2017.012.
  • He, X., Tan, C., Wang, F., Wang, Y., Zhou, R., Cui, D., You, W., Zhao, H., Ren, J., & Feng, B.* (2016). Knock-in of large reporter genes in human cells via CRISPR/Cas9-induced homology-dependent and independent DNA repair. Nucleic Acids Research, 44(9), e85.
  • Wang, Y., Qin, J., Wang, S., Zhang, W., Duan, J., Zhang, J., Wang, X., Yan, F., Chang, M., Liu, X., Feng, B., Liu, J., & Pei, X. (2016). Conversion of Human Gastric Epithelial Cells to Multipotent Endodermal Progenitors using Defined Small Molecules. Cell Stem Cell, 19(4), 449-461.
  • Wang, X.W., He, X.J., Lee, K.C., Huang, C., Hu, J.B., Zhou, R., Xiang, X.Y., Feng, B.*, & Lu, Z.Q.* (2016). MicroRNA-221 sponge therapy attenuates neointimal hyperplasia and improves blood flows in vein grafts. Int J Cardiol, 208, 79-86.
  • Liu, S., Xu, Y., Zhou, Z., Feng, B.*, & Huang, H.* (2015). Progress and challenges in generating functional hematopoietic stem/progenitor cells from human pluripotent stem cells. Cytotherapy, 17(4), 344-358.
  • Tu, J., Ng, S.H., Luk, A.C., Liao, J., Jiang, X., Feng, B., Mak, K.L.K., Rennert, O.M., Chan, W.Y., & Lee, T.L. (2015). MicroRNA-29b/Tet1 regulatory axis epigenetically modulates mesendoderm differentiation in mouse embryonic stem cells. Nucleic Acids Research, 43(16), 7805-7822.
  • Hu, J., Lei, Y., Wong, W.K., Liu, S., Lee, K.C., He, X., You, W., Zhou, R., Guo, J.T., Chen, X., Peng, X., Sun, H., Huang, H., Zhao, H., & Feng, B.* (2014). Direct activation of human and mouse Oct4 genes using engineered TALE and Cas9 transcription factors. Nucleic Acids Research, 42(7), 4375-4390.
  • Ma, H., Ng, H.M., Teh, X., Li, H., Lee, Y.H., Chong, Y.M., Loh, Y.H., Collins, J.J., Feng, B., Yang, H., & Wu, Q. (2014). Zfp322a Regulates mouse ES cell pluripotency and enhances reprogramming efficiency. PLoS Genet, 10(2), e1004038.
  • Lu, X., Goke, J., Sachs, F., Jacques, P.E., Liang, H., Feng, B., Bourque, G., Bubulya, P.A., & Ng, H.H. (2013). SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells. Nat Cell Biol, 15(10), 1141-1152.
  • Do, D.V., Ueda, J., Messerschmidt, D.M., Lorthongpanich, C., Zhou, Y., Feng, B., Guo, G., Lin, P.J., Hossain, M.Z., Zhang, W., Moh, A., Wu, Q., Robson, P., Ng, H.H., Poellinger, L., Knowles, B.B., Solter, D., & Fu, X.Y. (2013). A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo. Genes Dev, 27(12), 1378-1390.
  • Tsang, W.H., Wang, B., Wong, W.K., Shi, S., Chen, X., He, X., Gu, S., Hu, J., Wang, C., Liu, P.C., Lu, G., Zhao, H., Poon, W.S., Chan, W.Y., & Feng, B.* (2013). LIF-dependent primitive neural stem cells derived from mouse ES cells represent a reversible stage of neural commitment. Stem Cell Research, 11(3), 1091-1102.
  • Chan, Y.S., Goke, J., Lu, X., Venkatesan, N., Feng, B., Su, I.H., & Ng, H.H. (2012). A PRC2-dependent repressive role of PRDM14 in human embryonic stem cells and induced pluripotent stem cell reprogramming. Stem Cells, 31(4), 682-692.
  • Chia, N.Y., Chan, Y.S., Feng, B.#, Lu, X., Orlov, Y.L., Moreau, D., Kumar, P., Yang, L., Jiang, J., Lau, M.S., Huss, M., Soh, B.S., Kraus, P., Li, P., Lufkin, T., Lim, B., Clarke, N.D., Bard, F., & Ng, H.H. (2010). A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature, 468(7321), 316-320.
  • Heng, J.C., Feng, B.#, Han, J., Jiang, J., Kraus, P., Ng, J.H., Orlov, Y.L., Huss, M., Yang, L., Lufkin, T., Lim, B., & Ng, H.H. (2010). The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell, 6(2), 167-174.
  • Im, C. N., Kang, N.Y., Ha., H.H., Bi, X., Lee, J.J., Park, S.J., Lee, S.Y., Vendrell, M., Kim, Y.K., Lee, J.S., Li, J., Ahn, Y.H., Feng, B., Ng, H.H., Yun, S.W., & Chang, Y.T. (2010). A fluorescent rosamine compound selectively stains pluripotent stem cells. Angew Chem Int Ed Engl, 49(41), 7497-7500.
  • Feng, B., Jiang, J., Kraus, P., Ng, J.H., Heng, J.C., Chan, Y.S., Yaw, L.P., Zhang, W., Loh, Y.H., Han, J., Vega, V.B., Cacheux-Rataboul, V., Lim, B., Lufkin, T., & Ng, H.H. (2009). Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat Cell Biol, 11(2), 197-203.
  • Feng, B., Ng, J.H., Heng, J.C., & Ng, H.H. (2009). Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells. Cell Stem Cell, 4(4), 301-312.

* Co-correspondence author
# Co-first author