Professor Pang Chi Pui Calvin

Professor Pang Chi Pui Calvin

CUHK Employment

S.H. Ho Research Professor of Visual Sciences

Department of Ophthalmology & Visual Sciences

Faculty of Medicine

The Chinese University of Hong Kong

Phone number

+852 3943 5816

Email

cppang@cuhk.edu.hk

Researcher ID

https://publons.com/researcher/2508529/chi-p-pang/

Web of Science ResearchID: I-5388-201

Research Theme

Ophthalmology and Visual Sciences

Biography

Prof Pang received a BSc (Hon) in Biochemistry in 1978, University of London, and DPhil in 1982, University of Oxford, on an EP Abraham Research Fund Scholarship, followed by postdoctoral research in Oxford. In 1983, he was appointed Lecturer in Chemical Pathology at the Chinese University of Hong Kong (CUHK) and became a Professor in 1995. In 1998, Prof Pang moved to the Department of Ophthalmology and Visual Sciences (DOVS) of CUHK. He was Chairman of DOVS during 2012-2015. Prof Pang has served as academic assessor and reviewer for the Wellcome Trust (UK), National Eye Institute (USA), ARVO (USA), National Medical Research Council (Singapore), Health Research Board (Ireland), Catalan Agency for Health Technology Assessment and Research (Spain), National Science Foundation China, Changjiang Scholar Program China, and more than 20 funding organisations in different parts of the world. He is also an academic reviewer, external examiner and honorary or visiting professor of more than 60 clinical, research and academic institutions in Hong Kong, mainland China and overseas, including University of Melbourne, Purdue University, National University of Singapore, Peking University, Shanghai Fudan University, Zhejiang University, University of Hong Kong and Hong Kong Polytechnic University. He is convener and coordinator of the visual sciences programmes of Asia Pacific Academy of Ophthalmology (APAO), World Ophthalmology Congress (WOC), International Society for Eye Research (ISER) and other congresses. He has been co-chair of Asia-ARVO and APAO congresses, and has delivered > 300 invited lectures nationally and internationally. Prof Pang received the China State Scientific and Technological Progress Award (SSTPA) second-class award in 2016, Special Achievement Award of Chinese Ophthalmological Society in 2017, and Senior Achievement Award, APAO in 2018. In 2017 Prof Pang delivered the National Institute of Health – Global Health Vision Lecture, Bethesda, USA. In 2018 Prof Pang became a Fellow of ARVO and has been honoured as the 2020 ARVO honoree. Prof Pang has contributed >470 papers in international indexed peer reviewed journals, 25 book chapters, edition of 3 journal special issues and 1 book, and more than 700 abstracts in international conference proceedings. Sum of the Times Cited: >18,500. h-index: 72 (Source: Google Scholar)

Education

1978 BSc (hons), University of London, UK

1982 DPhil, University of Oxford, UK

Research Interest

  1. Molecular genomics, whole-genome sequencing, exome sequencing, and whole-genome association studies, on primary open angle glaucoma, primary angle closure glaucoma, age-related macular degeneration, polypoidal choridal vasculopathy, myopia, uveitis, congenital cataracts.
  2. Gene mapping and identification, mechanisms, and epi-genetics of glaucoma, macular diseases, retinoblastoma, myopia, uveitis, thyroid eye diseases, diabetic retinopathy, retinitis pigmentosa, keratoconus, cornea dystrophies and others.
  3. Biology of human trabecular meshwork cells, human periodontal ligament-derived neural crest stem cells, limbal stem cells, corneal progenitor cells, adipose tissue derived stromal cells, retinoblastoma cells, and retinal ganglion cells.
  4. Biological effects, metabolomics, proteomics, animal models (optic nerve crush, retina degeneration, experimental induced uveitis, experimental autoimmune uveoretinitis), pharmacokinetics of small herbal molecules, green tea extract, catechins, neuropeptides of agonists and antagonists of growth hormone-releasing hormone receptor in ocular oxidative stress, inflammations, and degeneration.
  5. Constitutive and inductive risk factors of children eye diseases. The concept of health care through children eye care.

Specialisations

Visual sciences

Qualification

BSc (Lond), DPhil(Oxon), FARVO

Award and Honour

2020 ARVO Foundation Honoree, USA

2018 Senior Achievement Award, Asia Pacific Academy of Ophthalmology

2018 Silver Fellowship, Association of Research in Vision and Ophthalmology, USA

2017 Dr APJ Abdul Kalam Aditya Jyot Endowment Oration, Mumbai, India.

2017 National Institute of Health – Global Health Vision Lecture, Bethesda, USA

2017 Special Achievement Award, Chinese Ophthalmological Society, China

2016 State Scientific and Technological Progress Award (SSTPA) second-class award, China

Others

Honorary Appointment

  1. Member, Academic Committee, Ocular neuro injury and repair, Beijing City Key Laboratory.
  2. Member, Ophthalmology Basis Research Advancement Committee, Chinese Ophthalmological Society, Chinese Medical Association.
  3. Director of Research & Chairman of Academic Committee, Joint Shantou International Eye Center.
  4. Director, Visual Science Research Laboratories, School of Ophthalmology, Capital University of Medical Sciences, Tongren Hospital, Beijing.
  5. Director, Aier Research Institute of Ophthalmology, Central South University
  6. Member, Academic Committee, Department of Ophthalmology, Peking University.
  7. Haiju Scholar, Beijing Health Bureau.
  8. Member, International Advisory Board, State Key Laboratory in Ophthalmology, Zhongshan Ophthalmic Center.
  9. Laboratory Director and Professor, Shenyang Eye Research Institute.
  10. Member, Academic Committee, Fujian Ophthalmology & Visual Sciences Key Laboratory
  11. Academic Advisor, Eye Research Institute, Xiaotung University, Shanghai
  12. Academic specialist, Ningxia Hui Autonomous Region Peoples’ Government.
  13. Member, Academic Committee, Shandong Province Ophthalmology Research Key Laboratory
  14. Member, Academic Committee, Chongqing Visual Impairment and Regeneration Key Laboratory
  15. Professor, Shantou University Medical College
  16. Honorary Professor, Zhongshan Ophthalmic Center
  17. Honorary Professor, Wenzhou Medical University
  18. Honorary Professor, Shenzhen Eye Hospital.
  19. Honorary Professor, Beijing Armed Police General Hospital.
  20. Honorary Professor, Beijing Hospital.
  21. Honorary Professor, Shanghai Institute of Medical Genetics.
  22. Visiting Professor, Central South University.
  23. Visiting Professor, Peking University
  24. Visiting Professor, Harbin Medical University
  25. Visiting Professor, Ningxia Eye Hospital.
  26. Visiting Professor, 4th Peoples’ Hospital of Shenyang
  27. Visiting Professor, Jinan University, Guangzhou.
  28. Visiting Professor, Guangdong Medical College, Shenjiang.
  29. Visiting Professor, Shanghai Fudan University.
  30. Visiting Professor, Southeast University, Nanjing.
  31. Visiting Professor, Third Military Medical University, Chongqing.
  32. Visiting Professor, Shanghai Jiaotong (Second Medical) University.

Editorship

  1. Associate Editor: Eye and Vision
  2. Section Editor Visual Sciences, Clinical Experimental Ophthalmology
  3. Member of Editorial Board, Asia Pacific Journal of Ophthalmology
  4. Member of Editorial Board, Clinical Biochemistry

Professional Service

  1. 2018-present Vice-President, Asia-Pacific Myopia Society
  2. Association for Research in Vision and Ophthalmology ARVO:
    (i) 2018: Silver Fellow
    (ii) 2015: Member, Executive Vice President (EVP) Nominating Committee
    (iii) 2014, 2015: Member, ARVO Strategic Plan Steering Committee, Global Presence Pillar
    (iv) 1999- present: Regular member
  3. Scientific secretary, Asia-Pacific Society of Eye Genetics
  4. Scientific Board, Global Eye Genetics Consortium (GEGC)
  5. Member, International Glaucoma Genetics Consortium (IGGC)
  6. Member, Consortium for Refractive Errors and Myopia (CREAM)
  7. Member, Keratoconus International Consortium
  8. 1998-2002 Consultant, Committee on Molecular Biology Techniques, International Federation of Clinical Chemistry

Academic Engagement

  1. Supervision and mentorship of >20 post-doctoral research fellows/associates at CUHK
  2. Supervision and mentorship of >30 visiting research scholars from mainland China at CUHK
  3. Supervision of >30 PhD and 4 MPhil students, all have their degrees conferred at CUHK.
  4. External examiner of >25 PhD candidates: University of Hong Kong, Polytechnic University of Hong Kong, Beijing Capital Medical University, Shantou University, National University of Singapore, Shanghai Fudan University, and Zhejiang University.
  5. External examiner of <40 Masters candidates: University of Hong Kong, Polytechnic University of Hong Kong, Nanjing Southeast University, Chongqing Third Military Medical University, Guangdong Medical College, and Shantou University.
  6. Internal examiner of >50 PhD, 10 MPhil and 6 MSc candidates, CUHK.

Publications

Selected Publications out of 472: *correspondence or senior author

  1. Yam JC, Li FF, Zhang X, ……., Pang CP.* Two-Year Clinical Trial of the Low-concentration Atropine for Myopia Progression (LAMP) Study: Phase 2 Report, Ophthalmology. 2020;127:910-19.
  2. Liang WC, Ren JL, Yu QX, ……, Pang C.P*, Chan SO (2020) Signaling mechanisms of growth hormone-releasing hormone receptor in LPS-induced acute ocular inflammation. Proc Natl Acad Sci USA 2020;117:6067-74.
  3. Qin YJ, Chan SO, Lin HL, ……, Pang CP*, Zhang HY. Increased expression of growth hormone-releasing hormone in fibrinous inflammation of proliferative diabetic retinopathy. Am J Ophthalmol 2020;215:81-90
  4. Yam JC, Jiang Y, Tang SM, ……, Tham CC, Chen LJ, Pang CP*. Low-concentration Atropine for Myopia Progression (LAMP) Study: A randomized, double-blinded, placebo-controlled trial of 0.05%, 0.025% and 0.01% Atropine eye drops in myopia control. Ophthalmology. 2019;126:113-24.
  5. Chu KO, Chan KP, Chan SO, Ng TK, Jhanji V, Wang CC, Pang CP*. Metabolomics of green-tea catechins on vascular endothelial growth factor stimulated human endothelial cell survival. J Agric Food Chem 2018;66:12866-75.
  6. Cen LP, Ng TK, Liang JJ, ……, Pang CP*. Human Periodontal Ligament-Derived Stem Cells Promote Retinal Ganglion Cell Survival and Axon Regeneration After Optic Nerve Injury. Stem Cells. 2018;36:844-55.
  7. Wang YM, Ng TK, Choy KW, Wong HK, Chu WK, Pang CP*, Jhanji V. Histological and microRNA Signatures of Corneal Epithelium in Keratoconus. J Refract Surg. 2018;34:201-11.
  8. Ma L, Brelen ME, Tsujikawa M, ……, Pang CP, Chen LJ. Identification of ANGPT2 as a New Gene for Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in the Chinese and Japanese Populations. Invest Ophthalmol Vis Sci. 2017;58:1076-83.
  9. Chu WK, Law KS, Chan SO, ……., Pang CP*. Antagonists of growth hormone-releasing hormone receptor induce apoptosis specifically in retinoblastoma cells. Proc Natl Acad Sci USA. 2016;113:14396-401.
  10. Khor CC, Do T, Jia H, … Pang CP, …., Aung T. Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma. Nat Genet. 2016;48:556-62.
  11. Huang L, Zhang H, Cheng CY,…., Pang CP*, Yoshimura N, Yang Z. A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy. Nat Genet. 2016;48:640-7.
  12. Chen LJ, Ma L, Chu WK, ……, Pang CP*. Identification of PGF as a new gene for neovascular age-related macular degeneration in a Chinese population. Invest Ophthalmol Vis Sci. 2016 Apr;57:1714-20.
  13. Chu KO, Chan KP, Yang YP, ……, Pang CP*. Effects of EGCG content in green tea extract on pharmacokinetics, oxidative status and expression of inflammatory and apoptotic genes in the rat ocular tissues. J Nutr Biochem. 2015;26:1357-67.
  14. Ma L, Li Z, Liu K, ……, Pang CP, Chen H, Chen LJ. Association of genetic variants with polypoidal choroidal vasculopathy: A systematic review and updated meta-analysis. Ophthalmology. 2015;122:1854-65.
  15. Huang LZ, Li YJ, Xie XF,…, Pang CP, Wong TY, Khor CC, Zhang K, Zhou P, Li XX. Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations. Nat Commun. 2015;6:6687.
  16. Cheng CY, Yamashiro K, Pang CP, Yoshimura N, Yin Wong T, Khor CC. New loci and coding variants confer risk for age-related macular degeneration in East Asians. Nat Commun. 2015;6:6063
  17. Qin YJ, Chan SO, Chong KK, ……, Pang CP*. Antagonist of GH-releasing hormone receptor alleviates experimental ocular inflammation. Proc Natl Acad Sci USA 2014;111:18303-8
  18. Chen Y, Lin Y, Vithana EN, ……., Pang CP*, Sun X, Yang Z. Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma. Nat Genet. 2014;46:1115-9.
  19. Hou S, Du L, Lei B, Pang CP, …… Yang Z, Yang P. Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome identifies two new susceptibility loci at 1p31.2 and 10q21.3. Nat Genet. 2014;46:1007-11.
  20. Liu K, Chen LJ, Lai TY, ………, Pang CP*. Genes in the high-density lipoprotein metabolic pathway in age-related macular degeneration and polypoidal choroidal vasculopathy. Ophthalmology. 2014;121:911-6.
  21. Yang Y, Ng TK, Ye C, ……, Pang CP*. Assessing sodium iodate induced outer retinal changes in rats using confocal scanning laser ophthalmoscopy and optical coherence tomography. Invest Ophthalmol Vis Sci. 2014;55:1696-705
  22. Khor CC, Miyake M, Chen LJ,.…., Pang CP, Saw SM, Yoshimura N. Genome-wide association study identifies ZFHX1B as a susceptibility locus for severe myopia. Hum Mol Genet. 2013;22:5288-94.
  23. Lu Y, Vitart V, Burdon KP, ….., Pang CP, ……., Wong TY. Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Nat Genet. 2013;45:155-63.
  24. Liu K, Chen LJ, ……., Pang CP*. Associations of the C2-CFB-RDBP-SKIV2L locus with age-related macular degeneration and polypoidal choroidal vasculopathy. Ophthalmology. 2013;120:837-43
  25. Vithana EN, Khor CC, Qiao C……, Pang CP, Wang N, Aung T. Genome-wide association analyses identify three new susceptibility loci for primary angle closureglaucoma. Nat Genet. 2012;44:1142-6.
  26. Thorleifsson G, Walters GB, Hewitt AW,….,Pang CP, ……Stefansson K. Sequence variants near the CAV1 and CAV2 genes associate with primary open angle glaucoma. Nat Genet 2010;42:906-9.
  27. Lee SK, Teng Y, Wong HK, ……, Pang CP*. MicroRNA-145 Regulates Human Corneal Epithelial Differentiation. PLoS One 2011;6:e21249.
  28. Chu KO, Chan KP, Wang CC, ……, Pang CP*. Green tea catechins and their oxidative protection in the rat eye. J Agric Food Chem. 2010;58:1523-34.
  29. Lam CY, Tam POS, Fan DSP, …, Pang CP*, Lam DSC. A genome-wide scan maps a novel high myopia locus to 5p15. Invest Ophthalmol Vis Sci 2008;49:3768-78.
  30. DeWan A, Liu M, Hartman S,……, Pang CP*, Hoh J. HTRA serine protease predisposes Asians to age- related macular degeneration. Science 2006;314:989-92.