Our research is patient orientated. We are committed to research of paediatric eye diseases at the highest standard and using state-of-the-art technologies. We conduct clinical research, laboratory based basic research and community research.
Principal Investigator:
Prof Chee Yung Clement Tham, Prof Chi Pui Calvin Pang, Dr Cheuk Sing Jason Yam, Dr Li Jia Guy Chen, Dr Wai Kit Chu
Research Team:
Dr Shiyao Lu, Dr Hei Nga Ruby Chan, Ms Oi Sin Pancy Tam
Retinoblastoma:
Clinical service for the whole of Hong Kong at Hong Kong Children’s Hospital (HKCH) headed by Prof Jason Yam. We have an RB cohort of all patients from the past 20 years with DNA, blood, tumour and primary cultured cell samples.
Paediatric glaucoma:
Establishment of clinical services and research with Hospital Authority (HA) colleagues at HKCH.
Childhood myopia:
Investigation and studies on high, extreme and pathological myopia.
Paediatric diabetic retinopathy:
Currently 600 diabetes cases at HKCH are followed-up once a year for fundus, optical coherence tomography (OCT), optical coherence tomography angiography (OCTA) and refraction.
Inherited retina diseases:
Establish retinitis pigmentosa screening and genetic tests for other inherited retina diseases at HKCH.
Comprehensive eye examinations provided by Prof. Jason Yam
Opening ceremony of our CUHK Jockey Club Children’s Eye Care Programme and CUHK Jockey Club Ophthalmic Microsurgical Training Programme
Selected publications:
- Li, F.F., Zhang, Y., Zhang, X., Yip, B.H.K., Tang, S.M., Kam, K.W., Young, A.L., Chen, L.J., Tham, C.C., Pang, C.P. and Yam, J.C. Age Effect on Treatment Responses to 0.05%, 0.025%, and 0.01% Atropine: Low-Concentration Atropine for Myopia Progression Study. Ophthalmology, 2021.
- Tang, S.M., Li, F.F., Lu, S.Y., Kam, K.W., Tam, P.O.S., Tham, C.C., Pang, C.P., Yam, J.C.S. and Chen, L.J. Association of the ZC3H11B, ZFHX1B and SNTB1 genes with myopia of different severities. Br J Ophthalmol, 2020. 104(10): p. 1472-1476.
- Li, F.F., Kam, K.W., Zhang, Y., Tang, S.M., Young, A.L., Chen, L.J., Tham, C.C., Pang, C.P. and Yam, J.C. Differential Effects on Ocular Biometrics by 0.05%, 0.025%, and 0.01% Atropine: Low-Concentration Atropine for Myopia Progression Study. Ophthalmology, 2020. 127(12): p. 1603-1611.
- Jiang, Y., Yam, J.C., Tham, C.C., Pang, C.P. and Chu, W.K. RB Regulates DNA Double Strand Break Repair Pathway Choice by Mediating CtIP Dependent End Resection. Int J Mol Sci, 2020. 21(23).
- Yam, J.C., Jiang, Y., Tang, S.M., Law, A.K.P., Chan, J.J., Wong, E., Ko, S.T., Young, A.L., Tham, C.C., Chen, L.J. and Pang, C.P. Low-Concentration Atropine for Myopia Progression (LAMP) Study: A Randomized, Double-Blinded, Placebo-Controlled Trial of 0.05%, 0.025%, and 0.01% Atropine Eye Drops in Myopia Control. Ophthalmology, 2019. 126(1): p. 113-124.
- Chu, W.K., Law, K.S., Chan, S.O., Yam, J.C., Chen, L.J., Zhang, H., Cheung, H.S., Block, N.L., Schally, A.V. and Pang, C.P. Antagonists of growth hormone-releasing hormone receptor induce apoptosis specifically in retinoblastoma cells. Proc Natl Acad Sci U S A, 2016. 113(50): p. 14396-14401.