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Professor WANG Chi-chiu Ronald

  • Head, Division of Obstetrics & Gynaecology
  • Professor, Department of Obstetrics & Gynaecology
  • Director, Chinese University of Hong Kong – Sichuan University Joint Laboratory for Reproductive Medicine
  • Principal Investigator, Reproduction and Development Laboratory, Li Ka Shing Institute of Health Sciences
  • Associate Member, Neural, Vascular, and Metabolic Biology, School of Biomedical Sciences
  • Deputy Director, Prenatal Genetics Diagnosis Centre

Biography

After MBBS education and training with honors, Ronald Wang devoted his career to research in Faculty of Medicine, The Chinese University of Hong Kong since 1995. Ronald conducted many clinical research and laboratory experiments in Prince of Wales Hospital, Hong Kong and Westmead Hospital, University of Sydney, NSW Australia, and was awarded Ph.D. degree in Surgical Science in 1998 and PhD in Genetics in 2011. He held many international scholarships and awards for analytical chemistry, molecular genetics and genomic and proteomic bioinformatics training at Institute for Biochemistry at Humboldt University zu Berlin, Germany (DAAD fellowship) in 1999; Center for Information Biology & DDBJ, National Institute of Genetics, Japan (JSPS fellowship) in 2001; Microarray Bioinformatics Centre, University of Oxford, UK in 2002; and also for his professional development in Clinical Biochemistry and Molecular Pathology (Roche Award of HKSCC in 2002; APCCB Regional Service Award in 2004 & AACC International Travel Grant in 2005). Ronald also had been Embryology Research Unit, Children’s Medical Research Institute, NSW Australia for molecular embryology research; and Department of Biomedical Science, Regeneration Medicine and Biofunction, Tottori University, Japan for stem cell research. Ronald is now teaching undergraduates and postgraduates and doing basic science and clinical research in the university.

  • MBBS (1st Hon.)
  • MMed (O&G)
  • PhD (O&G)
  • PhD (Genetics)
  • Reproduction
  • Development
  • Genetics
  • Obstetrics and Gynaecology
  • SAB (US)
  • FRSC (UK)
  • Honorary Consultant, Department of Paediatrics, Prince of Wales Hospital
  • Foreign Expert for Gynecological Cancer, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou.
  • Member, Center for Tissue Regeneration and Engineering, The Hong Kong University of Science and Technology.
  • Professor (Visiting), State Key Laboratory of Chinese Medicine Modernization, Innovation Center of Yangtze River Delta, Zhejiang University, Hangzhou
  • Professor (Visiting), Anhui Province Maternity & Child Health Hospital, Hefei
  • Professor (Visiting), Youjiang Medical University for Nationalities, Guangxi
  • Professor (Distinguished), Provincial Key Laboratory, Jiangxi University of Traditional Chinese Medicine, Nanchang
  • Professor (Honorary), Faculty of Medicine, Jinan University, Guangzhou
  • Professor (Honorary), School of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou
  • Professor (Honoary), Department of Obstetrics & Gynaecology, Sun Yat-Sen University, Guangzhou
  • Professor (by courtesy), Department of Ophthalmology and Visual Sciences, CUHK
  • Researcher Fellow (by courtesy), Shenzhen Research Institute, CUHK, Shenzhen
  • Honorary Scientific Officer (Medical), New Territories East Cluster, Hong Kong
  • Editorial Board Member, Hong Kong Journal of Paediatrics
  • Editorial Board Member, Respirology
  • Associate Editor, Frontiers in Pediatric Pulmonology
  • Kendig’s Disorders of the Respiratory Tract in Children
  • Fertility & Reproduction
  • Best Practice & Research Clinical Obstetrics & Gynaecology
  • Cell Press: Heliyon, section Clinical Research
  • Fertility & Reproduction
  • Nature: Scientific Report
  • Cell Press: Heliyon, section Women’s Health
  • Cell Press: Heliyon, section Genetics
  • Springer Nature: Uterine Immunity and Reproductive Disorders
  • Frontiers in Medicine (Obstetrics and Gynecology Section)
  • Biomedicines
  • Evidence-Based Complementary and Alternative Medicine
  • Project Steering Committee of Board of Reproductive Medicine (BRM), World Federation of Chinese Medicine Societies (WFCMS), Beijing, China
  • NMRC National Medical Research Council
  • IEP International Expert Panel
  • Project Sterring Committee of Board of Reproductive Medicine (BRM), World Federation of Chinese Medicine Societies (WFCMS), Beijing, China
  • Specialist Committee, National Research Foundation (NRF)
  • NMRC National Medical Research Council
  • IEP International Expert Panel
  • Macau Down Syndrome Association
  • Chemical Safety Management Subcommittee, Prince of Wales Hospital, New Territories East Cluster, Hospital Authority, Hong Kong
  • Centre of Excellence in Pediatrics and the Regional Hospitals, Hospital Authority, Hong Kong
  • MB.ChB for Med1/2/3/4/5;
  • MSc for Department of O&G, Ophthalmology & Visual Sciences, Chemical Pathology; RPgs
  • Principal and Co-/Bench Supervision: Total: 78; PhD: 62, MPhil: 12, MSc: 4
  • US Provisional (63/784,872)
  • WIPO/PCT (PCT/CN2024/115026)
  • US Provisional (63/562,932)
  • US Provisional (63/518,903)
  • WIPO/PCT (PCT/CN/2023/112278)
  • US Provisional (63/526,392)
  • WIPO/PCT (PCT/CN2024/103266)
  • US Provisional (63-363,226)
  • SIPO (17-024,206), SIPO 202110760679.4
  • US Provisional (63/211,946)
  • SIPO 202110567731.4, US 17/024,206
  • SIPO (CN202010494622.X)
  • SIPO 201820311468.6
  • SIPO (201510147995.9)
  • US Provisional (62/141,136)
  • SIPO (201420561288.5), 15111955.3
  • SIPO (201380052717.4)
  • USPTO (9713603)
  • USPTO (11045445)
  • WIPO/PCT (WO 2014/029327 A1)
  • US Provisional (61/684-852)
  • CUHK Startup GynaeSolution Limited

Selected publications

  • Tlaye KG, Woldeamanuel GG, Wong KCY, Chen L, Zheng RQ, So PK, Wang XQ, Long NH, Mei Z, SO HC, Leung BW, Huang Y, Wang Y, Poon LC*, Wang CC*. 2025 The pharmacogenomics and pharmacokinetics of aspirin in preeclampsia prevention. Circ Res 137(1), 69-82. doi:10.1161/CIRCRESAHA.124.325699
  • Woldeamanuel GG, Tlaye KG, Wang XQ, Long NH, Zhou QJ, Wang YN, Leung BW, Wang Y, Poon JC, Wang CC*. 2025 Platelets in preeclampsia: an observational study of indices associated with aspirin nonresponsiveness, activation and transcriptional landscape. BMC Med 23;Art. 346:1-20. doi:10.1186/s12916-025-04132-9
  • Liu BHM, Lin YZ, Long X, Hung SW, Gaponova A, Ren F, Zhavoronkov A, Pun FW*, Wang CC*. 2024 Utilizing AI for the identification and validation of novel therapeutic targets and repurposed drugs for endometriosis. Adv Sci Adv Sci 12(5):e2406565:1-15. doi: 10.1002/advs.202406565
  • Hu HY, Ma J, Peng Y, Feng RX, Luo CL, Zhang MY, Tao ZX, Chen L, Zhang T, Chen WQ, Yin Q, Zhai JG, Chen J, Yin AL*, Wang CC*, Zhong M*. 2024 Thrombospondin-1 regulates trophoblast necroptosis via NEDD4-mediated ubiquitination of TAK1 in preeclampsia. Adv Sci 11(21), Art 2309002:1-13. doi:10.1002/advs.202309002
  • Gao L, Mathur V, Tam SKM, Zhou XM, Cheung MF, Chan LY, Gutierrez GE, Leung BW, Moungmaithong S, Wang CC, Poon LC, Leung D. 2023 Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal-fetal interface following SARS-CoV-2 infection. Nat Cell Biol 25(7):1047-1060. doi: 10.1038/s41556-023-01169-x
  • Wu XK, Gao JS, Ma HL, Wang Y, Zhang B, Liu ZL, Li J, Cong J, Qin HC, Yang XM, Wu Q, Chen XY, Lu ZL, Feng YH, Qi X, Wang YX, Yu L, Cui YM, An CM, Zhou LL, Hu YH, Li L, Cao YJ, Yan Y, Liu L, Liu YX, Liu ZS, Painter RC, Ng EHY, Liu JP, Mol BWJ, Wang CC. 2023 Acupuncture and doxylamine/pyridoxine for nausea and vomiting in pregnancy: A randomized controlled two-by-two factorial trial. Ann Intern Med 176(7):922-933. doi: 10.7326/M22-2974
  • Donega V, Geest AT, Sluijs JA, Dijk RE, Wang CC, Basak O, Pasterkamp RJ, Hol EM. 2022 Single-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors. Nat Commun 3,Art 1036, 1-12. doi:10.1038/s41467-022-28626-9
  • Wu XK*, Stener-Victorin E*, Kuang HKY, Ma HL, Gao JS, Xie LZ, Hou LH, Hu ZX, Shai XG, Ge J, Zhang JF, Xue HY, Xu ZF, Liang RN, Ma HX, Yang HW, Li WL, Huang DM, Sun Y, Hao CF, Du SM, Yang ZW, Wang X, Yan Y, Chen XH, Fu P, Ding CF, Gao YQ, Zhou ZM, Wang CC, Wu TX, Liu JP, Ng EHY, Legro RS, Zhang HP. 2017 Effect of acupuncture and clomiphene in Chinese women with polycystic ovary syndrome a randomized clinical trial. JAMA 317(24):2502-2514. doi:10.1001/jama.2017.7217
  • Lui NC, Tam WY, Gao CJ, Huang JD, Wang CC, Jiang LW, Yung WH, Kwan KM*. 2017 Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin. Nat Commun 8:15079. doi: 10.1038/ncomms15079
  • Kai Y†, Wang CC, Kishigami S, Kazuki Y, Abe S, Takiguchi M, Wakayama T, Shirayoshi Y, Inoue T, Ito H, Oshimura M*. 2009 Enhanced apoptosis during early neuronal differentiation in mouse ES cells with autosomal imbalance. Cell Research 19(2): 247-258. DOI:10.1038/cr.2008. (equal 1st author)