Eye Diseases
Research Interests
Focus on Paediatric eye diseases
Description of research topics:
Our research is patient orientated. We are committed to research of paediatric eye diseases at the highest standard and using state-of-the-art technologies. We conduct clinical research, laboratory based basic research and community research.
- Retinoblastoma
Clinical service for the whole of Hong Kong at Hong Kong Children’s Hospital (HKCH) headed by Prof Jason Yam. We have an RB cohort of all patients from the past 20 years with DNA, blood, tumour and primary cultured cell samples. - Paediatric glaucoma
Establishment of clinical services and research with Hospital Authority (HA) colleagues at HKCH. - Childhood myopia
Investigation and studies on high, extreme and pathological myopia. - Paediatric diabetic retinopathy
Currently 600 diabetes cases at HKCH are followed-up once a year for fundus, optical coherence tomography (OCT), optical coherence tomography angiography (OCTA) and refraction. - Inherited retina diseases
Establish retinitis pigmentosa screening and genetic tests for other inherited retina diseases at HKCH
Principal Investigator
Professor Chee Yung Clement Tham
- Chairman, Department of Ophthalmology and Visual Sciences
- S.H. Ho Professor of Ophthalmology & Visual Sciences
- Honorary Consultant of Ophthalmology Service In Hong Kong Children′s Hospital
- Director, CUHK Eye Centre
- Director, Lam Kin Chung. Jet King-Shing Ho Glaucoma Treatment and Research Centre
- Deputy Director, Joint Shantou International Eye Centre (JSIEC) of Shantou University and The Chinese University of Hong Kong
Professor Chi Pui Calvin Pang
- S. H. Ho Research Professor of Visual Sciences
- Director, Joint Shantou International Eye Center (JSIEC) of Shantou University and The Chinese University of Hong Kong
Professor Cheuk Sing Jason Yam
- Professor, Department of Ophthalmology and Visual Sciences
- Head and Honorary Consultant, Paediatric Ophthalmology and Strabismus Service, Hong Kong Eye Hospital
- Head, Undergraduate Division, Department of Ophthalmology and Visual Sciences
- Dean of General Education, Chung Chi College, The Chinese University of Hong Kong
- Director, CUHK Jockey Club Myopia Prevention Programme
Professor Li Jia Guy Chen
- Professor, Department of Ophthalmology and Visual Sciences
- Head, Graduate Division of Ophthalmology and Visual Sciences
- Associate Director (Medical), CUHK Jockey Club Myopia Prevention Programme
Doctor Wai Kit Chu
- Research Assistant Professor, Department of Ophthalmology and Visual Sciences
- Director, CUHK Department of Ophthalmology & Visual Sciences Laboratories
- Associate Head, Graduate Division of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong
- Chair-Elect, Global Members Committee, Association for Research in Vision and Ophthalmology (ARVO)
Research Team Member
- Dr. Jingna He, Postdoctoral Scientist
- Dr. Lin Du, Postdoctoral Scientist
- Dr. Linbin Zhou, Postdoctoral Scientist
- Ms. Oi Sin Pancy Tam, Laboratory Manager
Related Publications
Selected Publications
- Yam, J.C., Zhang,, X.J., Zhang, Y.Z., Yip, B.H.K., Tang, F.Y., Wong, E., Bui, C.H.T., Kam, K.W., Ng, M.P.H., Ko, S.T.C., Yip, W.W.K., Young, A.L., Tham, C.C., Chen, L.J., Pang, C.P.-. Effect of Low-concentration Atropine Eyedrops vs Placebo on Myopia Incidence in Children: The LAMP2 Randomized Clinical Trial. JAMA. 2023, 329(6):472-481.
- Li, F.F., Zhang, Y., Zhang, X., Yip, B.H.K., Tang, S.M., Kam, K.W., Young, A.L., Chen, L.J., Tham, C.C., Pang, C.P. and Yam, J.C.Age Effect on Treatment Responses to 0.05%, 0.025%, and 0.01% Atropine: Low-Concentration Atropine for Myopia Progression Study. Ophthalmology, 2021.
- Li, F.F., Kam, K.W., Zhang, Y., Tang, S.M., Young. A.L.., Chen, L.J., Tham, C.C., Pang, C.P. and Yam, J.C. Differential Effects on Ocular Biometrics by 0.05%, 0.025%, and 0.01% Atropine: Low-Concentration Atropine for Myopia Progression Study.Ophthalmology. 2020. 127(12): p. 1603-1611.
- Jiang, Y., Yam, J.C., Tham, C.C., Fang, C.P. and Chu, W.K. RB Regulates DNA Double Strand Break Repair Pathway Choice by Mediating CtIP Dependent End Resection. Int J Mol Sci, 2020. 21(23).
- Yam, J.C., Jiang, Y., Tang, S.M., Law, A.K.P., Chan, J.J., Wong, E., Ko, S.T., Young, A.L.., Tham, C.C., Chen, L.J. and Pang, C.P.Low-Concentration Atropine for Myopia Progression (LAMP) Study: A Randomized, Double-Blinded, Placebo-Controlled Trial of 0.05%, 0.025%, and 0.01% Atropine Eye Drops in Myopia Control. Ophthalmology, 2019. 126(1): p. 113-124.
Chu, W.K., Law, K.S., Chan, S.O., Yam, J.C., Chen, L.J., Zhang. H., Cheung, H.S., Block, N.L.., Schally, A.V. and Pang, C.P. Antagonists of growth hormone-releasing hormone receptor induce apoptosis specifically in retinoblastoma cells. Proc Nati Acad Sci U S A, 2016. 113(50): p. 14396-14401.
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